Related Experiment Video

Updated: Aug 15, 2026

Profiling of Estrogen-regulated MicroRNAs in Breast Cancer Cells
16:24

Profiling of Estrogen-regulated MicroRNAs in Breast Cancer Cells

Published on: February 21, 2014

Oestrogen receptors in relation to human breast cancer

H Braunsberg

    La Ricerca in Clinica E in Laboratorio
    |January 1, 1977
    PubMed

    Insights

    Accurate measurement of oestrogen receptors in breast cancer is crucial for predicting treatment response. Improved assay methods can better distinguish hormone-responsive tumors, optimizing endocrine therapy selection.

    Area of Science:

    • Endocrinology
    • Oncology
    • Molecular Biology

    Background:

    • Hormone responsiveness is a key concept in human breast cancer treatment.
    • Oestrogen's mode of action in target tissues is under ongoing investigation.
    • Oestrogen receptor assays are vital for predicting response to endocrine therapy.

    Purpose of the Study:

    • To review current understanding of oestrogen action and receptor assays in breast cancer.
    • To discuss challenges and recent advancements in oestrogen receptor determination.
    • To explore the potential of improved receptor assays for patient selection in endocrine therapy.

    Main Methods:

    • Review of existing literature on oestrogen receptor assays and hormone responsiveness.
    • Analysis of results from oestrogen receptor assays in various human tumour types.
    • Discussion of methods for oestrogen receptor separation, estimation, and error analysis.

    Main Results:

    • Oestrogen receptor assay results correlate with clinical response to endocrine therapy.
    • Variations in oestrogen receptor forms within tumours may influence treatment outcomes.
    • Receptor assays in male breast cancer, benign tumors, and non-breast cancers were reviewed.

    Conclusions:

    • Accurate oestrogen receptor determinations are essential for discriminating hormone-responsive from unresponsive breast tumors.
    • Further research is needed on receptor integrity and the effects of hormone treatment.
    • Improved patient selection for endocrine therapy may result from refined receptor assay techniques.

    More Related Videos

    An Ex vivo Model to Study Hormone Action in the Human Breast12:31

    An Ex vivo Model to Study Hormone Action in the Human Breast

    Published on: January 8, 2015

    Systems Biology of Metabolic Regulation by Estrogen Receptor Signaling in Breast Cancer10:36

    Systems Biology of Metabolic Regulation by Estrogen Receptor Signaling in Breast Cancer

    Published on: March 17, 2016

    Related Concept Videos

    Oogenesis02:07

    Oogenesis

    In human women, oogenesis produces one mature egg cell or ovum for every precursor cell that enters meiosis. This process differs in two unique ways from the equivalent procedure of spermatogenesis in males. First, meiotic divisions during oogenesis are asymmetric, meaning that a large oocyte (containing most of the cytoplasm) and minor polar body are produced as a result of meiosis I, and again following meiosis II. Since only oocytes will go on to form embryos if fertilized, this unequal...
    Mitogens and the Cell Cycle02:38

    Mitogens and the Cell Cycle

    Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
    Transducer Mechanism: Nuclear Receptors01:31

    Transducer Mechanism: Nuclear Receptors

    Nuclear receptors, or NRs, are unique transcription factors that regulate gene transcription and affect the cellular pathways involved in reproduction, development, or metabolism. Their ability to be stimulated by small lipophilic ligands and control vital cellular processes makes them ideal drug targets. Nearly 10-15% of currently prescribed drugs target these receptors.
    About 48 different soluble family members of nuclear receptors are identified that can be divided into two main classes:
    Target Cell Response to Hormones01:22

    Target Cell Response to Hormones

    Hormones intricately bind to receptors on the surface or within target cells, initiating a cascade of cellular responses.
    Notably, the cellular response can be regulated by altering the number of receptors expressed in the cell. For example, prolonged exposure to elevated hormone levels results in a gradual decline or down-regulation in the number of receptors for that specific hormone on the cell surface. Conversely, in response to low hormone levels, cells may use up-regulation, producing an...