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Related Experiment Videos

Angiotensin and the brain

B Andersson1, S Eriksson, M Rundgren

  • 1Department of Physiology & Pharmacology, Karolinska Institutet, Stockholm, Sweden.

Acta Physiologica Scandinavica
|October 1, 1995
PubMed
Summary
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The brain has its own renin-angiotensin system (RAS) that influences blood pressure, water, and salt balance. Angiotensin II (Ang II) in the brain affects these systems via specific targets.

Area of Science:

  • Neuroscience
  • Endocrinology
  • Physiology

Background:

  • The renal renin-angiotensin system (RAS) plays a crucial role in regulating blood pressure and fluid balance.
  • Evidence suggests the presence of an intrinsic RAS within the brain.

Purpose of the Study:

  • To review the cerebral RAS, its components, and targets.
  • To explore the central effects of angiotensin II (Ang II) on physiological systems.

Main Methods:

  • Literature review focusing on the cerebral RAS and its actions.
  • Analysis of studies investigating Ang II's impact on the central nervous system.

Main Results:

  • The brain possesses a functional RAS, distinct from the renal system.

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  • Circumventricular organs are key targets for blood-borne Ang II in the brain.
  • Central Ang II influences cardiovascular regulation, water and sodium balance, and hormonal secretion (ACTH-cortisol).

    • Conclusions:

    • The brain's intrinsic RAS is a significant regulator of homeostatic functions.
    • Targeting central RAS components offers potential therapeutic avenues for related disorders.