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Related Experiment Videos

Chaotic oscillations in microvessel arterial networks

S Cavalcanti1, M Ursino

  • 1Department of Electronics, Computer Science and Systems, University of Bologna, Italy.

Annals of Biomedical Engineering
|January 1, 1996
PubMed
Summary

A mathematical model shows that the myogenic reflex in arterioles can create complex, irregular oscillations (vasomotion). Changes in arterial pressure can lead to periodic, quasiperiodic, or chaotic behavior in microvascular networks.

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Area of Science:

  • Physiology
  • Biophysics
  • Mathematical Biology

Background:

  • Microvascular networks exhibit irregular oscillations known as vasomotion.
  • The myogenic reflex plays a crucial role in regulating microvascular tone.
  • Understanding vasomotion mechanisms is key to comprehending microcirculatory regulation.

Purpose of the Study:

  • To investigate the mechanisms generating irregular oscillations in arteriolar microvessels using a mathematical model.
  • To explore the role of the myogenic reflex in producing complex oscillatory patterns.
  • To analyze the impact of arterial pressure on microvascular network behavior.

Main Methods:

  • Developed a biomechanical model of a multibranched microvascular network.
  • Simulated the passive and active (myogenic) response of arterioles to arterial pressure changes.

Related Experiment Videos

  • Analyzed model bifurcations with respect to arterial pressure levels to identify transitions in oscillatory behavior.

    • Main Results:

    • Each arteriole can act as an autonomous oscillator within a specific pressure range due to the myogenic reflex.
    • Interactions among oscillators in the network generated diverse oscillatory patterns, including periodic, quasiperiodic, and chaotic behavior.
    • A classic route toward chaos was observed as arterial pressure varied from 60-150 mm Hg.

    Conclusions:

    • The nonlinear myogenic mechanism can produce the wide range of oscillatory patterns observed in vivo.
    • Irregular microvascular fluctuations can be understood as a form of deterministic chaos.
    • Mathematical modeling provides insights into the complex dynamics of microvascular networks.