Related Experiment Videos
Lack of expression of c-erbB-2 oncoprotein in human esophageal squamous cell carcinomas
1Department of Pathology, Norwegian Radium Hospital, Oslo, Norway. zhenhes@radium.uio.no
Anticancer Research
|November 1, 1995
Abstract:
Fifty-one cases of esophageal squamous cell carcinoma were immunohistochemically investigated with monoclonal c-erbB 2 oncoprotein antibody. No tumor showed plasma membrane immunostaining for c-erbB-2 protein. Occasionally, unspecific cytoplasmic staining was found in minor tumor cell populations. The present results show that c-erbB-2 oncoprotein is not overexpressed in esophageal squamous cell carcinomas and does not play a central role in the tumorigenesis.