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Synthesis and antiplatelet activity of 1-tert-butylamino-3-(3-thienyloxy)-2-propanols
S Abdallah1, V Darias, R Donoso
1Deparmento de Farmacognosia y Farmacodinamia, Facultad de Farmacia, Universidad de La Laguna, Tenerife, Spain.
Archiv Der Pharmazie
|April 1, 1996
Abstract:
The synthesis of new 1-tert-butylamino-3-(3-thienyloxy)-2-propanols by two alternative methods is described. Their initial antiplatelet activity evaluation against ADP, adrenaline, and collagen is reported, and the preliminary structure-activity relationships are established. The appropriateness of further pharmacological investigations, especially for the best compound of the series 1f, is indicated.