Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cannabinoids inhibit testosterone secretion by mouse testes in vitro

S Dalterio, A Bartke, S Burstein

    Science (New York, N.Y.)
    |June 24, 1977
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    In situ hybridization study of growth hormone, prolactin, and proopiomelanocortin mRNAs in adenohypophyses of mice transgenic for human growth hormone.

    Endocrine pathology·2020
    Same author

    Aging in the Syrian hamster testis: Inflammatory-oxidative status and the impact of photoperiod.

    Experimental gerontology·2019
    Same author

    Ageing and inflammation in the male reproductive tract.

    Andrologia·2018
    Same author

    Ovarian aging and the activation of the primordial follicle reserve in the long-lived Ames dwarf and the short-lived bGH transgenic mice.

    Molecular and cellular endocrinology·2016
    Same author

    Growth hormone actions during development influence adult phenotype and longevity.

    Experimental gerontology·2016
    Same author

    Effects of adult onset mild calorie restriction on weight of reproductive organs, plasma parameters and gene expression in male mice.

    Animal reproduction·2013

    Cannabis compounds, including delta-9-tetrahydrocannabinol and cannabinol, significantly reduce testosterone production in mouse testes. This suggests cannabis directly impacts male reproductive function by inhibiting steroidogenesis.

    Area of Science:

    • Endocrinology
    • Reproductive Biology
    • Pharmacology

    Background:

    • Cannabis use is associated with male reproductive and sexual dysfunction.
    • The precise mechanisms underlying these effects are not fully understood.
    • Testicular steroidogenesis is crucial for male reproductive health.

    Purpose of the Study:

    • To investigate the direct effects of key cannabis compounds on testicular testosterone production.
    • To determine if cannabis constituents can inhibit steroidogenesis in testicular tissue.

    Main Methods:

    • Decapsulated mouse testes were incubated in a medium.
    • Delta-9-tetrahydrocannabinol (THC) and cannabinol were added to the incubation medium.
    • Testosterone accumulation in the medium was measured.

    Related Experiment Videos

    Main Results:

    • Both delta-9-tetrahydrocannabinol and cannabinol significantly reduced testosterone accumulation.
    • The inhibitory effect was observed directly within the testicular incubation medium.

    Conclusions:

    • Cannabis constituents, including THC and cannabinol, can directly inhibit testicular steroidogenesis.
    • These findings provide a potential mechanism for the adverse effects of cannabis on male reproductive function.