Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The hippocampo-neocortical dialogue

G Buzsáki1

  • 1Center for Molecular and Behavioral Neuroscience, Rutgers, State University of New Jersey, Newark 07102, USA.

Cerebral Cortex (New York, N.Y. : 1991)
|March 1, 1996
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Efficient assembly of multi-color fiberless optoelectrodes with on-board light sources for neural stimulation and recording.

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference·2017
Same author

Physiological and behavioral consequences of delayed septal grafts in the subcortically denervated hippocampus.

Restorative neurology and neuroscience·2011
Same author

Persisting axonal degeneration in the hippocampus after transection of the fimbria-fornix.

Restorative neurology and neuroscience·2011
Same author

Morphology and synaptic input of substance P receptor-immunoreactive interneurons in control and epileptic human hippocampus.

Neuroscience·2006
Same author

Developmental emergence of hippocampal fast-field "ripple" oscillations in the behaving rat pups.

Neuroscience·2005
Same author

Capillary level imaging of local cerebral blood flow in bicuculline-induced epileptic foci.

Neuroscience·2004

The hippocampus modifies neocortical information by integrating external content and internal context. This hippocampal-neocortical information transfer occurs in discrete stages, potentially over extended periods.

Area of Science:

  • Neuroscience
  • Cognitive Neuroscience
  • Neuroanatomy

Background:

  • The hippocampus, an archicortex structure, is anatomically linked to the neocortex.
  • Hippocampal inputs include external information (content) via the entorhinal cortex and internal information (context) via subcortical inputs.
  • Subcortical inputs conveying context are crucial for hippocampal function, as their removal causes significant behavioral impairment.

Purpose of the Study:

  • To propose a hypothesis on the primary function of the hippocampal formation.
  • To elucidate the role of the hippocampus in modifying neocortical information processing.
  • To investigate the temporal dynamics of neocortico-hippocampal information transfer and modification.

Main Methods:

  • Anatomical analysis of hippocampal input-output connections.

Related Experiment Videos

  • Hypothetical modeling of information processing and transfer.
  • Consideration of neurophysiological states (theta/gamma oscillations, slow wave sleep) in information processing.

    • Main Results:

    • The hippocampus is proposed to modify inputs by sending a processed "reafferent copy" back to the neocortex.
    • Neocortico-hippocampal information transfer and neocortical modification are hypothesized to be temporally discontinuous, occurring over minutes, hours, or days.
    • Information acquisition may be rapid during hippocampal activation (theta/gamma oscillations), while consolidation and transfer are protracted, occurring during slow-wave sleep.

    Conclusions:

    • The hippocampus plays a critical role in integrating and modifying information from both external and internal sources.
    • Information processing and transfer between the hippocampus and neocortex are complex, involving distinct phases and temporal scales.
    • The findings suggest a dynamic model of memory formation and consolidation involving rapid acquisition and slower, sleep-dependent transfer and modification.