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Related Experiment Videos

Adipocyte insulin action during the normal menstrual cycle

P J Marsden1, A Murdoch, R Taylor

  • 1Centre for Reproductive Medicine, Royal Victoria Infirmary, Queen Victoria Road, Newcastle upon Tyne NE1 4LP, UK.

Human Reproduction (Oxford, England)
|May 1, 1996
PubMed
Summary

Insulin sensitivity varies during the menstrual cycle. Adipose tissue shows reduced insulin receptor binding in the luteal phase, but post-receptor insulin action remains unaffected.

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Area of Science:

  • Endocrinology
  • Metabolic Health
  • Reproductive Physiology

Background:

  • The interplay between the menstrual cycle and insulin sensitivity requires further elucidation.
  • Adipose tissue, a key insulin target organ, plays a crucial role in metabolic regulation.

Purpose of the Study:

  • To investigate alterations in insulin sensitivity throughout the normal menstrual cycle.
  • To examine insulin receptor binding and action in adipose tissue during follicular and luteal phases.

Main Methods:

  • Studied 23 healthy volunteers, divided into follicular (n=9) and luteal (n=14) phases.
  • Measured adipocyte insulin receptor binding.
  • Assessed adipocyte insulin action via 3-O-methylglucose uptake and lipolysis inhibition.

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Main Results:

  • Significantly higher insulin receptor binding in the follicular phase compared to the luteal phase (P < 0.05).
  • No significant differences in 3-O-methylglucose transport rates between phases.
  • No significant difference in the inhibition of lipolysis between follicular and luteal phases.

Conclusions:

  • Insulin receptor binding in adipose tissue is reduced during the luteal phase of the menstrual cycle.
  • Post-receptor insulin action remains consistent across both follicular and luteal phases.