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Related Experiment Videos

A 'sweet' indication for ovulation induction

Y Peled1, D Rabinerson, B Kaplan

  • 1Department of Obstetrics and Gynecoloy, Rabin Medical Center, Beilinson Campus, Petah Tiqva, Israel.

Human Reproduction (Oxford, England)
|July 1, 1996
PubMed
Summary
This summary is machine-generated.

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Clomiphene citrate enhanced fertility in 10 diabetic patients, leading to successful pregnancies. The drug did not negatively impact diabetes control, suggesting a new use for improving outcomes in diabetic pregnancies.

Area of Science:

  • Reproductive Endocrinology
  • Diabetology
  • Obstetrics

Background:

  • Euglycaemia at conception is vital for successful pregnancy in diabetic patients.
  • Achieving and maintaining tight glycemic control pre-conception is challenging.
  • Poor glycemic control increases risks during pregnancy.

Purpose of the Study:

  • To evaluate clomiphene citrate's efficacy in enhancing fecundability in pregestational diabetic patients.
  • To assess the safety of clomiphene citrate regarding glycemic control in diabetic pregnancies.

Main Methods:

  • Administered clomiphene citrate to 10 pregestational diabetic patients.
  • Monitored conception rates and pregnancy outcomes.
  • Assessed glycemic control using glycosylated hemoglobin and fructosamine levels, and insulin requirements.

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Main Results:

  • All 10 patients conceived within 1-3 cycles.
  • Nine patients delivered healthy term babies after uneventful pregnancies.
  • One patient experienced a spontaneous abortion at 8 weeks.
  • No adverse effects on diabetes control were observed.

Conclusions:

  • Clomiphene citrate effectively enhances fecundability in pregestational diabetic patients.
  • The drug appears safe for diabetic patients, with no negative impact on glycemic control.
  • Suggests a new indication for clomiphene citrate to improve early pregnancy outcomes in diabetic women.