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Identification of a 2-D geometric descriptor associated with non-genotoxic carcinogens and some estrogens and
H S Rosenkranz1, A Cunningham, G Klopman
1Department of Environmental and Occupational Health, University of Pittsburgh, PA 15238, USA.
Mutagenesis
|January 1, 1996
Abstract:
A distance descriptor (6A) originally associated with non-genotoxic mouse carcinogens has been found to be present in some, but not all, estrogens and antiestrogens. It is hypothesized that this descriptor describes a ligand binding site on an estrogen receptor. Evidence is presented that those estrogens and antiestrogens not containing the 6A distance bind to a different receptor. It is conceivable that binding to the receptor that recognizes the 6A distance is associated with carcinogenicity.