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Related Experiment Videos

Studies on Bermuda grass pollen allergens

A Orren, E B Dowdle

    South African Medical Journal = Suid-Afrikaanse Tydskrif Vir Geneeskunde
    |April 23, 1977
    PubMed
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    Bermuda grass pollen contains two allergens, BGP-1 and BGP-2. BGP-1 is a major allergen, while BGP-2 is minor, with potential dimer relationship discussed.

    Area of Science:

    • Allergy and Immunology
    • Biochemistry
    • Molecular Biology

    Background:

    • Bermuda grass pollen is a common allergen.
    • Allergenic components of pollen extracts require detailed characterization for effective diagnosis and treatment.

    Purpose of the Study:

    • To identify and characterize allergens in Bermuda grass pollen extract.
    • To investigate the relationship between identified allergens.

    Main Methods:

    • Crude Bermuda grass pollen extract was analyzed.
    • Calibrated column chromatography was employed to determine molecular weights and Stokes radii.
    • Sucrose density gradient ultracentrifugation and iso-electric focusing were used for BGP-1 characterization.

    Main Results:

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    • Two allergens, BGP-1 (major) and BGP-2 (minor), were identified.
    • BGP-1: molecular weight 30,000 daltons, Stokes radius 24.3 x 10^-8 cm, S20,w 3.1, pI 5.4.
    • BGP-2: molecular weight 14,000 daltons, Stokes radius 18.1 x 10^-8 cm.
    • BGP-1 elicited reactions in 100% of sensitive subjects, BGP-2 in 75%.

    Conclusions:

    • BGP-1 and BGP-2 are distinct allergens in Bermuda grass pollen.
    • The differing reactivity suggests BGP-1 may be a dimer of BGP-2.
    • Further research is needed to confirm the dimer hypothesis and its clinical implications.