Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Uromucoids and urinary stone formation

P C Hallson, G A Rose

    Lancet (London, England)
    |May 12, 1979
    PubMed
    Summary
    This summary is machine-generated.

    Uromucoids, a protein found in urine, promote the formation and clustering of calcium oxalate and calcium phosphate crystals. This precipitation is hypothesized as the initial step in kidney stone development.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Effect of a novel viral filter on cardiopulmonary exercise testing during the COVID-19 pandemic.

    Anaesthesia·2021
    Same author

    AUTHORS' RESPONSE to Cardiorespiratory fitness in patients undergoing elective open surgery for abdominal aortic aneurysm: does it really fail to predict short-term postoperative mortality?

    Annals of the Royal College of Surgeons of England·2020
    Same author

    Cardiorespiratory fitness fails to predict short-term postoperative mortality in patients undergoing elective open surgery for abdominal aortic aneurysm.

    Annals of the Royal College of Surgeons of England·2020
    Same author

    Cardiorespiratory fitness is impaired and predicts mid-term postoperative survival in patients with abdominal aortic aneurysm disease.

    Experimental physiology·2018
    Same author

    The cardiopulmonary exercise test grey zone; optimising fitness stratification by application of critical difference.

    British journal of anaesthesia·2018
    Same author

    Examination of fine-scale spatial-temporal overlap and segregation between two closely related congeners Gadus morhua and Gadus ogac in coastal Newfoundland.

    Journal of fish biology·2014
    Same journal

    Assisted dying and the silencing of medicine's next generation.

    Lancet (London, England)·2026
    Same journal

    Linguistic pragmatism: a woman with progressive abdominal pain in Thailand.

    Lancet (London, England)·2026
    Same journal

    Medical compartmentalisation: a patient with chromosome 22q11.2 deletion syndrome in Japan.

    Lancet (London, England)·2026
    Same journal

    [<sup>177</sup>Lu]Lu-edotreotide versus everolimus for gastroenteropancreatic neuroendocrine tumours (COMPETE): a phase 3, multicentre, randomised, open-label, superiority trial.

    Lancet (London, England)·2026
    Same journal

    Research priorities for characterising Bundibugyo virus.

    Lancet (London, England)·2026
    Same journal

    Rethinking treatment sequence in advanced gastroenteropancreatic neuroendocrine tumours.

    Lancet (London, England)·2026
    See all related articles

    Area of Science:

    • Urology
    • Biochemistry
    • Crystallography

    Background:

    • Kidney stones are a common ailment with complex formation mechanisms.
    • The role of urinary proteins in crystal nucleation and aggregation is not fully understood.

    Purpose of the Study:

    • To investigate the role of uromucoids in the initial stages of calcium oxalate and calcium phosphate crystal formation.
    • To explore the potential of uromucoid precipitation as a precursor to kidney stone development.

    Main Methods:

    • Fresh urine samples were rapidly concentrated to standard osmolarity.
    • Crystallization was induced and observed at 37 degrees C using a rotary evaporator.
    • The influence of uromucoids on calcium oxalate and calcium phosphate precipitation was analyzed.

    Related Experiment Videos

    Main Results:

    • Uromucoids were found to promote the formation of both calcium oxalate and calcium phosphate crystals.
    • Uromucoids also induced the aggregation of calcium phosphate precipitates.
    • A correlation between uromucoid precipitation and initial stone formation was observed.

    Conclusions:

    • Uromucoid precipitation is postulated as the primary event in kidney stone formation.
    • Subsequent mineral deposition on uromucoid aggregates and attachment to renal tubules may occur.
    • Understanding uromucoid's role could lead to new strategies for preventing kidney stones.