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Some factors associated with mortality in perforated peptic ulcer: a case-control study
J H McIntosh1, K Berman, F M Holliday
1Department of Medicine, University of Sydney, New South Wales, Australia.
Journal of Gastroenterology and Hepatology
|January 1, 1996
Summary
Coexisting illnesses, septicaemia, and intra-abdominal abscess significantly increase mortality risk after peptic ulcer perforation. Moderate alcohol use, however, shows a negative association with mortality in these patients.
Area of Science:
- Gastroenterology
- Internal Medicine
- Epidemiology
Background:
- Peptic ulcer perforation is a serious condition with significant mortality.
- Understanding risk factors for mortality is crucial for improving patient outcomes.
Purpose of the Study:
- To identify factors associated with mortality in patients with peptic ulcer perforation.
- To examine the impact of comorbidities, infections, and lifestyle factors on outcomes.
Main Methods:
- A case-control study comparing patients who died (cases) with survivors (controls) of peptic ulcer perforation.
- Frequency matching for age, sex, and perforation site.
- Logistic regression analysis to determine associations with mortality.
Main Results:
- Comorbidities (cardiac, respiratory, cerebrovascular, renal, liver, malignant diseases), septicaemia, and intra-abdominal abscess were significantly associated with increased mortality.
- Widowed or never-married status increased mortality risk, while moderate alcohol use decreased it.
- Comorbidities were elevated in cases both on admission and at hospital discharge.
Conclusions:
- Coexisting illnesses, septicaemia, and intra-abdominal abscess are key risk factors for mortality following peptic ulcer perforation.
- The mortality risk associated with comorbidities remains consistent throughout hospitalization.
- Marital status and alcohol consumption also play a role in peptic ulcer perforation outcomes.
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