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Related Experiment Videos

Adenosine in acute theophylline intoxication

J C Blery1, M J Kauflin, V F Mauro

  • 1College of Pharmacy, University of Toledo, OH 43606, USA.

The Annals of Pharmacotherapy
|December 1, 1995
PubMed
Summary

Adenosine may theoretically help theophylline toxicity, but clinical data are lacking. Its risks, cost, and lack of evidence mean routine use in theophylline poisoning is not recommended currently.

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Area of Science:

  • Emergency Medicine
  • Clinical Pharmacology

Background:

  • Theophylline toxicity is a serious condition requiring emergent treatment.
  • Adenosine has theoretical benefits for managing theophylline toxicity due to its electrophysiological effects.

Purpose of the Study:

  • To evaluate the current clinical evidence for the efficacy and safety of adenosine in treating theophylline toxicity.
  • To determine if adenosine is a recommended treatment for acute theophylline ingestion.

Main Methods:

  • Review of published clinical data regarding adenosine use in theophylline toxicity.
  • Assessment of the risks and costs associated with adenosine infusions.

Main Results:

  • There is a lack of published clinical data supporting adenosine's efficacy and safety for theophylline toxicity.
  • Adenosine use carries inherent risks and can be expensive.

Conclusions:

  • Routine use of adenosine in acute theophylline ingestion cannot be recommended at this time.
  • Further clinical evidence is required before adenosine can be considered a standard treatment option.

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