Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Parathyroid localization with technetium-99m-sestamibi: a prospective evaluation

C R McHenry1, K Lee, J Saadey

  • 1Department of Surgery, MetroHealth Medical Center, Case Western Reserve University School of Medicine, Cleveland, OH 44109-1998, USA.

Journal of the American College of Surgeons
|July 1, 1996
PubMed
Summary

Technetium-99m-sestamibi (MIBI) scintigraphy shows high accuracy for parathyroid localization in primary hyperparathyroidism. However, its sensitivity is limited for multiglandular disease, necessitating continued bilateral neck exploration.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The biomechanical consequences of longirostry in crocodilians and odontocetes.

Journal of biomechanics·2017
Same author

The Extent of Surgery for Papillary Thyroid Microcarcinoma: The Controversy Continues.

World journal of surgery·2016
Same author

Constructing an Invasion Machine: The Rapid Evolution of a Dispersal-Enhancing Phenotype During the Cane Toad Invasion of Australia.

PloS one·2016
Same author

Mechanics of biting in great white and sandtiger sharks.

Journal of biomechanics·2010
Same author

Difficult problems in thyroid cancer surgery.

Minerva chirurgica·2010
Same author

An investigation of epidemiologic factors associated with large nodular goiter.

The Journal of surgical research·2006

Area of Science:

  • Nuclear Medicine
  • Endocrinology
  • Surgical Oncology

Background:

  • Hyperparathyroidism management relies on accurate parathyroid localization.
  • Technetium-99m-sestamibi (MIBI) scintigraphy is a common imaging modality.

Purpose of the Study:

  • To prospectively evaluate the efficacy of technetium-99m-sestamibi (MIBI) scintigraphy for parathyroid localization.

Main Methods:

  • 124 patients with hyperparathyroidism underwent MIBI scintigraphy.
  • Results were correlated with clinical and pathological findings, including serum calcium and parathyroid hormone (PTH) levels.

Main Results:

  • MIBI demonstrated 81% sensitivity and 89% positive predictive value for solitary adenomas.
  • Sensitivity decreased to 37% for multiglandular disease.

Related Experiment Videos

  • Associated thyroid disease was noted in 23% of patients.

    • Conclusions:

    • MIBI scintigraphy is effective for localizing solitary parathyroid adenomas.
    • Its limited sensitivity for multiglandular disease means it cannot replace bilateral neck exploration.