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Multiple cerebral cavernous angiomas. Case report

H Kroh1, J Andrychowski

  • 1Neurosurgery Department, School of Medicine, Warszawa.

Folia Neuropathologica
|January 1, 1995
PubMed
Summary

A rare case of multiple cavernous angiomas, initially presenting as increased intracranial pressure, was diagnosed only at autopsy. This highlights the diagnostic challenges of this condition, even with advanced imaging and treatment over two decades.

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Area of Science:

  • Neurology
  • Neurosurgery
  • Pathology

Background:

  • Cavernous angiomas are rare vascular malformations that can present with diverse neurological symptoms.
  • Diagnosis can be challenging, often requiring advanced neuroimaging techniques.

Observation:

  • A 26-year-old woman presented with symptoms of increased intracranial pressure, visual disturbances, hemiparesis, hemianesthesia, and epileptic fits over 20 years.
  • Initial investigations including CT scans showed hyperdense foci, and ventriculography revealed hydrocephalus and a tumor in the third ventricle region.
  • A ventriculo-peritoneal shunt was placed, providing temporary improvement.

Findings:

  • Despite initial management, the patient's condition progressively worsened over two decades.
  • The definitive diagnosis of multiple cavernous angiomas was only established post-mortem.

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Implications:

  • This case underscores the importance of considering rare diagnoses in complex neurological presentations.
  • It highlights potential limitations in diagnosing diffuse cavernous angiomas, even with serial neuroimaging.
  • Delayed or missed diagnosis can lead to significant morbidity and mortality.