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Related Experiment Videos

Antithrombin and atherosclerosis in the Rotterdam Study

J G van der Bom1, M L Bots, H H van Vliet

  • 1Department of Epidemiology, Erasmus University Medical School, Rotterdam, Netherlands.

Arteriosclerosis, Thrombosis, and Vascular Biology
|July 1, 1996
PubMed
Summary

Antithrombin levels vary with atherosclerosis severity. Activity increases with moderate peripheral arterial disease but decreases in severe cases in men, suggesting a complex relationship with cardiovascular risk.

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Area of Science:

  • Cardiovascular Medicine
  • Hematology
  • Epidemiology

Background:

  • Antithrombin is a key inhibitor of thrombosis.
  • The relationship between antithrombin levels and atherosclerosis is not well-defined, with conflicting previous study results.
  • The ankle-brachial index (ABI) serves as a marker for peripheral arterial disease.

Purpose of the Study:

  • To investigate the association between antithrombin activity and atherosclerosis in an elderly population.
  • To explore potential gender-specific differences in this association.

Main Methods:

  • The Rotterdam Study, a population-based cohort study, analyzed 1427 participants (aged 55+) not using anticoagulants.
  • Measurements included antithrombin activity and the ankle-brachial index (ABI).

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  • Statistical analyses examined associations, controlling for cardiovascular risk factors.

    • Main Results:

    • A quadratic association was observed in men: antithrombin activity increased with moderate atherosclerosis and decreased with severe atherosclerosis.
    • A linear association was found in women: lower ABI correlated with higher antithrombin activity.
    • These associations remained significant after adjusting for smoking, BMI, lipids, fibrinogen, and factor VIIc.

    Conclusions:

    • Antithrombin activity may increase in response to cardiovascular disease risk and the presence of atherosclerosis.
    • In men, antithrombin activity might decrease with advancing atherosclerosis severity, potentially explaining conflicting prior findings.
    • Dynamic changes in antithrombin could be valuable for predicting cardiovascular disease risk and progression.