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Related Experiment Videos

Pregnancy-associated lymphomas. A clinicopathologic study

A B Gelb1, M van de Rijn, R A Warnke

  • 1Department of Pathology, University of California, San Francisco 94143-0102, USA.

Cancer
|July 15, 1996
PubMed
Summary
This summary is machine-generated.

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Pregnancy outcomes for Hodgkin's disease (HD) and non-Hodgkin's lymphomas (NHL) are similar to non-pregnant patients. HD treatment can often be delayed until after delivery, while NHL patients present with more advanced disease and a worse prognosis.

Area of Science:

  • Oncology
  • Hematology
  • Obstetrics & Gynecology

Background:

  • The clinical course of Hodgkin's disease (HD) and non-Hodgkin's lymphomas (NHL) during pregnancy is not well-documented.
  • Understanding these natural histories is crucial for optimal patient management.

Purpose of the Study:

  • To review cases of HD and NHL diagnosed during pregnancy.
  • To compare the clinical behavior and outcomes of these lymphomas in pregnant versus non-pregnant individuals.
  • To evaluate the safety of deferring treatment for HD until after delivery.

Main Methods:

  • Retrospective review of all HD and NHL cases diagnosed during pregnancy at Stanford University Medical Center since 1987.
  • Clinical follow-up was obtained for all patients.
  • Immunohistochemical studies and in situ hybridization for Epstein-Barr virus (EBV) were performed on a subset of cases.

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Main Results:

  • Seventeen cases of HD and 12 cases of NHL were identified (median age 27).
  • HD patients typically presented with Stage II-III disease at 22 weeks gestation, with most deferring therapy until after delivery and having good outcomes.
  • NHL patients presented with Stage II-IV disease at 23 weeks gestation, exhibiting a trend towards poorer survival compared to HD patients (P=0.04).
  • EBV was not supported by in situ hybridization in the studied NHL cases.

Conclusions:

  • The clinical behavior of HD and NHL during pregnancy does not significantly differ from that in non-pregnant patients.
  • Selected HD cases may be safely treated after delivery.
  • NHL patients diagnosed during pregnancy tend to have higher stage disease and a poorer prognosis compared to HD patients.