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Occupational laryngitis with immediate allergic or immediate type specific chemical hypersensitivity
E Sala1, M Hytönen, O Tupasela
1Institute of Occupational Health, Helsinki, Finland.
Clinical Otolaryngology and Allied Sciences
|February 1, 1996
Summary
Allergic laryngitis can be triggered by organic substances and chemicals. This study confirms allergic reactions in 20 patients using provocation tests, identifying specific allergens.
Area of Science:
- Immunology
- Otolaryngology
- Occupational Health
Background:
- Allergic laryngitis is infrequently reported, with allergy often suspected but rarely confirmed.
- Previous diagnoses lacked rigorous confirmation through provocation testing.
Purpose of the Study:
- To demonstrate that organic substances and chemicals can cause laryngitis via immediate allergy or hypersensitivity.
- To confirm allergic laryngitis in patients through standardized diagnostic procedures.
Main Methods:
- Investigated 20 patients with suspected allergic laryngitis.
- Utilized provocation tests to confirm diagnosis by observing vocal cord changes.
- Performed skin-prick tests and measured specific IgE antibodies for suspected allergens.
Main Results:
- Confirmed allergic laryngitis in all 20 patients via provocation tests.
- Identified causative agents including flours, plants, acid anhydrides, formaldehyde, and acrylate compounds.
- 13 patients had positive skin-prick tests, and 11 of those showed elevated specific IgE levels.
Conclusions:
- Immediate allergic reactions or specific hypersensitivity to environmental agents can cause laryngitis.
- Provocation testing is crucial for confirming allergic laryngitis.
- Occupational and environmental exposures are significant contributors to allergic laryngitis.