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Related Experiment Videos

Bacterial translocation in experimental intestinal obstruction

M N Akçay1, M Y Capan, C Gündogdu

  • 1Department of General Surgery, School of Medicine, Atatürk University, Erzurum, Turkey.

The Journal of International Medical Research
|January 1, 1996
PubMed
Summary

Intestinal obstruction in rats led to bacterial translocation and histopathological changes, particularly with loop obstruction and delayed surgery. Escherichia coli was the most common bacteria found.

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Area of Science:

  • Gastroenterology
  • Surgical Pathology
  • Microbiology

Background:

  • Intestinal obstruction is a common surgical emergency.
  • Bacterial translocation and subsequent organ damage are significant complications.
  • Understanding the impact of obstruction type and surgical timing is crucial.

Purpose of the Study:

  • To investigate bacterial translocation to mesenteric lymph nodes (MLN), liver, and spleen in rats with intestinal obstruction.
  • To evaluate histopathological changes in the intestine, MLN, liver, and spleen following obstruction.
  • To compare the effects of simple vs. loop obstruction and different surgical re-intervention timings (12h vs. 24h).

Main Methods:

  • Wistar Albino rats were subjected to simple or loop intestinal obstruction.

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  • Groups were subdivided based on repeat laparotomy at 12 or 24 hours post-obstruction.
  • Bacterial cultures and histopathological examinations of MLN, liver, spleen, and intestine were performed.

    • Main Results:

    • No bacterial translocation occurred in the control group.
    • Highest incidences of bacterial translocation to MLN, liver, and spleen were observed in the loop obstruction group with 24h re-laparotomy.
    • Escherichia coli was the predominant cultured bacteria (48%).
    • Significant histopathological changes were most pronounced in the loop obstruction group with 24h re-laparotomy.

    Conclusions:

    • Intestinal obstruction promotes bacterial translocation and histopathological damage.
    • Loop obstruction and delayed surgical intervention (24h) exacerbate these complications.
    • Early surgical management is critical to mitigate bacterial translocation and organ damage in intestinal obstruction.