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Lectin-activated CD4+CD45RA+ T-lymphocytes have no ability to kill monocytes
1Department of Clinical Immunology and Microbiology, Polish-American Institute of Paediatrics, Jagiellonian University Medical College, Cracow, Poland.
Immunological Investigations
|January 1, 1996
Abstract:
Monocytes are eliminated from cell culture by antigen or mitogen activated cytotoxic CD4+ T-lymphocytes. In this report we asked the question whether CD4+CD45RA+ and CD4+CD45RO+ subpopulations differ in the ability to kill monocytes in pokeweed mitogen (PWM)-activated cultures. Data are presented that although CD4+CD45RA+ vigorously proliferate in the presence of PWM, they do not kill monocytes or secrete IFN gamma.