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Related Experiment Videos

Comparison between incremental and single-dose allergen administration in bronchial provocation tests

J B Wasserfallen1, P Leuenberger

  • 1Division of Allergy and Clinical Immunology, Department of Internal Medicine University Hospital, Lausanne, Switzerland.

The Journal of Asthma : Official Journal of the Association for the Care of Asthma
|January 1, 1996
PubMed
Summary

This study investigated allergen administration schedules in asthma patients. Results showed that early and late allergic reactions were consistent, regardless of the allergen challenge schedule.

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Area of Science:

  • Allergy and Immunology
  • Respiratory Medicine
  • Pulmonary Physiology

Background:

  • Asthma is characterized by variable airway inflammation and hyperresponsiveness.
  • Dual responders exhibit both early and late allergic reactions after allergen exposure.
  • Understanding the impact of allergen challenge protocols is crucial for accurate assessment.

Purpose of the Study:

  • To evaluate the influence of different allergen administration schedules on early (EAR) and late allergic reactions (LAR) in asthmatic patients.
  • To determine the reproducibility of allergic responses under varied bronchoprovocation test (BPT) conditions.
  • To assess the potential carry-over effect of prior allergen challenge on subsequent reactions.

Main Methods:

  • Fifteen asthmatic patients with a dual response underwent two consecutive bronchoprovocation tests (BPTs).

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  • BPT1 involved incremental allergen doses to achieve a 20% FEV1 drop.
  • BPT2 used the highest allergen dose from BPT1 two weeks later to assess reaction consistency.

    • Main Results:

    • Early allergic reactions (EAR) and late allergic reactions (LAR) were found to be highly similar for individual patients across both BPTs.
    • The allergen dose in BPT2 was lower than the cumulative dose in BPT1, controlling for potential prior sensitization effects.
    • The study design minimized the influence of bronchial hyperreactivity induced by the first BPT on the second.

    Conclusions:

    • Allergen administration schedules do not significantly alter the magnitude of early and late allergic reactions in dual responders.
    • The findings support the reliability of repeated allergen challenges in assessing allergic airway responses in asthma.
    • This protocol provides a robust method for studying allergic asthma phenotypes while accounting for potential test-induced changes in bronchial reactivity.