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Related Experiment Videos

Development of the cochlear amplifier

D M Mills1, E W Rubel

  • 1Virginia Merrill Bloedel Hearing Research Center, University of Washington, Seattle 98195-7923, USA. dmmills@u.washington.edu

The Journal of the Acoustical Society of America
|July 1, 1996
PubMed
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The cochlear amplifier

Area of Science:

  • Auditory Neuroscience
  • Otoacoustic Emissions
  • Mammalian Cochlear Physiology

Background:

  • The cochlear amplifier is crucial for hearing sensitivity and frequency selectivity.
  • Its development and maturation are key to understanding auditory system development.
  • Distortion product otoacoustic emissions (DPOAEs) provide a non-invasive measure of cochlear function.

Purpose of the Study:

  • To investigate the developmental trajectory of the cochlear amplifier's gain and passive thresholds in gerbils.
  • To correlate changes in cochlear amplifier function with age and frequency.
  • To explore the role of passive cutoff frequency in early auditory development.

Main Methods:

  • Utilized distortion product otoacoustic emissions (DPOAEs) in gerbils from 14 days post-natal to adulthood.

Related Experiment Videos

  • Measured DPOAEs during normal cochlear function and after pharmacological interruption (furosemide) to isolate passive emissions.
  • Calculated cochlear amplifier gain and passive threshold levels from input-output functions.

    • Main Results:

    • Cochlear amplifier gain reached adult levels by 14 days post-natal for mid-frequencies, but was absent at frequency extremes.
    • Gain increased significantly between 14-18 days post-natal, coinciding with endocochlear potential changes.
    • Passive thresholds improved with age, particularly at high frequencies, suggesting a rising passive base cutoff frequency.

    Conclusions:

    • Cochlear amplifier elements are functional early in development, but auditory function is limited by passive cutoff frequency.
    • The age-related increase in passive cutoff frequency explains the developmental shift in auditory place code.
    • This study elucidates critical developmental aspects of the cochlear amplifier and their impact on hearing maturation.