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Recurrent priapism as a side effect of zuclopenthixol decanoate
A M van Hemert1, W Meinhardt, D Moehadjir
1Psychiatric Hospital Bloemendaal, The Hague, The Netherlands.
International Clinical Psychopharmacology
|September 1, 1995
Summary
Priapism, a rare side effect of antipsychotics, can occur with zuclopenthixol. This thioxanthene medication may induce priapism, especially at higher doses or with combined use.
Area of Science:
- Pharmacology
- Neuroscience
- Urology
Background:
- Priapism is a recognized, albeit rare, adverse effect associated with specific phenothiazine antipsychotics.
- These medications are known for their significant alpha1-adrenergic blocking activity.
Observation:
- A case study details a patient experiencing recurrent priapism during treatment with zuclopenthixol decanoate.
- Zuclopenthixol belongs to the thioxanthene class of antipsychotics.
Findings:
- Despite having only moderate alpha-blocking potential, zuclopenthixol demonstrated the capacity to induce priapism.
- The occurrence of priapism appears dose-dependent or potentially linked to polypharmacy with other antipsychotic agents.
Implications:
- This finding suggests that zuclopenthixol, even with moderate alpha-blocking effects, should be considered a potential cause of priapism.
- Clinicians should exercise caution regarding dosage and concurrent antipsychotic use when prescribing zuclopenthixol to mitigate priapism risk.