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Co-immunoprecipitation of the Mouse Mx1 Protein with the Influenza A Virus Nucleoprotein
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A bispecific antibody recognizing influenza A virus M2 protein redirects effector cells to inhibit virus replication

A Fernandez-Sesma1, J L Schulman, T M Moran

  • 1Microbiology Department, Mount Sinai Medical Center, New York, New York 10029, USA.

Journal of Virology
|July 1, 1996
PubMed

Bispecific antibodies can be used to redirect cytotoxic T cells to kill virus-infected cells, overriding the need for major histocompatibility complex restriction. We produced a bispecific antibody (3F12) which binds influenza virus M2 protein and the T-cell receptor and can redirect staphylococcal enterotoxin B-activated T cells to kill influenza virus-infected cells and inhibit virus replication in vitro.

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