Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Tubuloglomerular feedback

S Ito1, K Abe

  • 1Second Department of Internal Medicine, Tohoku University School of Medicine, Sendai, Japan.

Japanese Heart Journal
|March 1, 1996
PubMed
Summary
This summary is machine-generated.

The macula densa regulates kidney function by sensing salt levels and controlling blood flow. Dysregulation of this tubuloglomerular feedback (TGF) mechanism is linked to diseases like hypertension and heart failure.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Different thresholds of HSP70 and HSC70 heat shock mRNA induction in post-ischemic gerbil brain.

Brain research·1992
Same author

[Mechanism of renin release and cellular action of angiotensin II].

Nihon Naibunpi Gakkai zasshi·1992
Same author

Ras (CXXX) and Rab (CC/CXC) prenylation signal sequences are unique and functionally distinct.

The Journal of biological chemistry·1992
Same author

Isolation of complementary DNAs for heat shock protein (HSP) 70 and heat shock cognate protein (HSC) 70 genes and the expressions in post-ischaemic gerbil brain.

Neurological research·1992
Same author

[DNA typing of HLA-class II genes in idiopathic nephropathy].

Nihon rinsho. Japanese journal of clinical medicine·1992
Same author

Effect of slow release nifedipine tablets in patients with essential hypertension.

Arzneimittel-Forschung·1992

Area of Science:

  • Nephrology
  • Physiology

Background:

  • The macula densa in the distal tubule monitors tubular fluid NaCl concentration.
  • This macula densa initiates tubuloglomerular feedback (TGF) to control glomerular hemodynamics.
  • TGF, alongside the myogenic response, is crucial for renal autoregulation.

Purpose of the Study:

  • To elucidate the role of the macula densa in renal function and homeostasis.
  • To understand the interaction between TGF and the renin-angiotensin system.
  • To explore the implications of TGF alterations in diseases like hypertension and diabetes mellitus.

Main Methods:

  • The abstract does not specify the methods used.
  • Further research is needed to identify the signaling mechanism of the macula densa.

Related Experiment Videos

Main Results:

  • Increased NaCl concentration at the macula densa constricts the afferent arteriole, reducing single-nephron GFR.
  • The macula densa influences renin release and angiotensin II levels.
  • Proper TGF and renin-angiotensin system interaction is vital for fluid and electrolyte balance.

Conclusions:

  • Alterations in TGF are implicated in the pathophysiology of hypertension, diabetes mellitus, and congestive heart failure.
  • The precise signal from the macula densa remains unidentified and requires further investigation.