Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Bone resorption markers]

M Takahashi1, T Inoue

  • 1Department of Orthopedic Surgery, Hamamatsu University School of Medicine, Japan.

Rinsho Byori. the Japanese Journal of Clinical Pathology
|May 1, 1996
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Transjugular intrahepatic portosystemic stent shunt (TIPSS) with use of Rösch-Uchida transjugular liver access set--evaluation by CT and its clinical application].

Nihon Igaku Hoshasen Gakkai zasshi. Nippon acta radiologica·1992
Same author

HPC-1 is associated with synaptotagmin and omega-conotoxin receptor.

The Journal of biological chemistry·1992
Same author

Cytohistologic assessment of antitumor effects of intraperitoneal hyperthermic perfusion with mitomycin C for patients with gastric cancer with peritoneal metastasis.

Cancer·1992
Same author

Structure of UvrABC excinuclease-UV-damaged DNA complexes studied by flow linear dichroism. DNA curved by UvrB and UvrC.

FEBS letters·1992
Same author

Quantitative HCV RNA and effect of interferon therapy in chronic hepatitis C.

Digestive diseases and sciences·1992
Same author

[13C] breath test of medium-chain triglycerides and oligosaccharides in neonates.

Acta paediatrica Japonica : Overseas edition·1992
Same journal

[The Role of Laboratory Medicine in Hematopoietic Stem Cell Transplantation "Echocardiogram"].

Rinsho byori. The Japanese journal of clinical pathology·2019
Same journal

[The Significance of Pulmonary Function Testing Before and After Allogeneic Stem Cell Transplantation].

Rinsho byori. The Japanese journal of clinical pathology·2019
Same journal

[Blood Transfusion Inspection].

Rinsho byori. The Japanese journal of clinical pathology·2019
Same journal

[The Role of Clinical Laboratory Technicians at Bone Marrow Transplantation : Blood Test].

Rinsho byori. The Japanese journal of clinical pathology·2019
Same journal

[The Foundation of Allogeneic Hematopoietic Stem Cell Transplantation and the Role of Clinical Laboratory Tests in This Field].

Rinsho byori. The Japanese journal of clinical pathology·2019
Same journal

[How to Interpret Data from Routine Laboratory Tests].

Rinsho byori. The Japanese journal of clinical pathology·2019
See all related articles

Newer bone resorption markers, pyridinoline (Pyr) and deoxypyridinoline (Dpyr) crosslinks, offer improved specificity over older methods. Assays for telopeptides like NTx and CrossLaps show promise for monitoring bone turnover.

Area of Science:

  • Biochemistry
  • Orthopedics
  • Endocrinology

Context:

  • Traditional bone resorption markers, urinary hydroxyproline and serum tartrate-resistant acid phosphatase, lack sensitivity and specificity.
  • Pyridinoline (Pyr) and deoxypyridinoline (Dpyr) are mature collagen crosslinks proposed as superior bone resorption markers since the late 1980s.

Purpose:

  • To review the background of Pyr and cross-linked telopeptide markers for bone resorption.
  • To compare the performance of these novel markers in postmenopause and established osteoporosis.

Summary:

  • Collagen degradation during bone resorption releases Pyr, Dpyr, and cross-linked telopeptides (NTx, CrossLaps, ICTP).
  • These markers are specific to bone resorption as they are not present during collagen synthesis.
  • Novel assays for NTx and CrossLaps in urine, and ICTP in serum, provide more accurate measurements.

Related Experiment Videos

Impact:

  • These specific bone resorption markers are expected to accurately reflect bone turnover in postmenopausal women and osteoporosis.
  • The development of sensitive and specific markers aids in understanding and managing bone diseases.
  • This review provides insights into the clinical utility of advanced bone resorption markers.