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Classification of lipid disorders in chronic hemodialyzed patients
E Król1, B Rutkowski, M Wróblewska
1Department of Nephrology, Gdansk School of Medicine, Poland.
Insights
The European Atherosclerosis Society
Area of Science:
- Nephrology
- Cardiology
- Clinical Chemistry
Background:
- Lipid disorders are common in patients with chronic renal failure.
- Dialysis therapy (DT) can impact lipid profiles.
- Accurate monitoring of lipid metabolism is crucial for these patients.
Purpose of the Study:
- To apply the European Atherosclerosis Society's A B C D E classification for monitoring lipid disorders.
- To evaluate lipid parameter changes in chronic renal failure patients during the first year of dialysis therapy.
- To compare the modified A B C D E classification with the Fredrickson classification.
Main Methods:
- Study included 41 chronically uremic patients undergoing dialysis therapy.
- Serum lipid parameters (total cholesterol, HDL-cholesterol, triglycerides) and lipoprotein electrophoresis were assessed.
- Measurements were taken before DT and every 2 months during the first year of DT.
Main Results:
- Initially, 63% of patients had normal lipid parameters before DT.
- After one year of DT, only 29% of patients maintained normal lipid parameters.
- Significant alterations in lipid profiles were observed during the study period.
Conclusions:
- The modified A B C D E classification is a practical tool for monitoring lipid disorders in hemodialyzed patients.
- Dialysis therapy is associated with a decline in normal lipid parameter values.
- The A B C D E classification offers advantages over the traditional Fredrickson classification for this patient group.
Abstract:
The aim of our study was to introduce the classification given by the European Atherosclerosis Society (A B C D E groups) for monitoring lipid disorders in chronic renal failure patients during the first year of dialysis therapy (DT). Studies were carried out in 41 chronically uremic patients (19 F, 22 M). Before the start of DT, and then every 2 months, following parameters were determined in the serum: total cholesterol, HDL-cholesterol and triglycerides. Moreover, electrophoresis of serum lipoproteins were also performed. At the start of the DT 63% of chronically uremic patients had normal values of basic lipid parameters, but this number decreased to only 29% after the first year of DT. We conclude that the modified A B C D E classification of lipid disorders in hemodialyzed patients is more convenient than the classic Fredrickson one used before.