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[Changes in red blood cell aggregation rate after aneurysmal subarachnoid hemorrhage]
1Department of Neurosurgery, Juntendo University Izunagaoka Hospital, Shizuoka, Japan.
No Shinkei Geka. Neurological Surgery
|June 1, 1996
Summary
Hypervolemic hemodilution therapy improved red blood cell (RBC) aggregability in subarachnoid hemorrhage patients. This therapy effectively reversed neurological decline by modulating key proteins like albumin and alpha 2-macroglobulin.
Area of Science:
- Biomedical Engineering
- Hematology
- Neurosurgery
Context:
- Subarachnoid hemorrhage (SAH) can lead to increased blood viscosity due to altered red blood cell (RBC) aggregability.
- Monitoring RBC aggregation is crucial in post-neurosurgical patients.
Purpose:
- To investigate the impact of hypervolemic hemodilution (H-H) therapy on RBC aggregability in patients after aneurysmal clipping surgery.
- To identify intravascular factors influencing RBC aggregation post-SAH.
Summary:
- RBC aggregation rate increased 5-7 days post-surgery in 38 SAH patients.
- H-H therapy significantly decreased RBC aggregation, correlating with changes in serum albumin and alpha 2-macroglobulin levels.
- Hematocrit also decreased with H-H therapy, while IgG and fibrinogen remained stable.
Impact:
- H-H therapy effectively improved RBC aggregability, suggesting a mechanism to counteract neurological deterioration.
- Serum albumin and alpha 2-macroglobulin are identified as key determinants of RBC aggregability after SAH.
- This finding supports H-H therapy as a treatment strategy for managing cerebral vasospasm post-SAH.