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[Nephrotoxicity evaluation of cytostatic agents in children with acute lymphoblastic leukemia]
B Tomaszewska1, W M Zoch-Zwierz
1I Klinika Chorób Dzieci Akademii Medycznej w Białymstoku.
Pediatria Polska
|November 1, 1995
Abstract:
Urinary excretion of the markers of tubular nephrotoxicity, total NAG and isoenzymes A and B and B-2-M, were evaluated in urine of 21 children with acute lymphoblastic leukaemia after the first injection of cytostatic administrated according to the BFM scheme: VCR + Rub, L-aspa, CY, Ara-C. Every administrated drug caused temporary elevation in urinary excretion of total NAG and isoenzyme B and B-2-M. GFR was unchanged. These results point to nephrotoxicity of cytostatics. Peak total NAG, isoenzyme B and B-2-M excretion was observed on the third day after L-aspa and Ara-C injection.