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[Mouse hepatitis virus]

F R Homberger1

  • 1Institut für Labortierkunde, Veterinärmedizinische Fakultät, Universität Zürich.

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Mouse hepatitis virus (MHV) is a significant pathogen in lab mice, causing varied diseases based on strain and host. Detection relies on serological screening, with control through culling or rederivation.

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Area of Science:

  • Virology
  • Immunology
  • Pathology

Context:

  • Mouse hepatitis virus (MHV) is a prevalent coronavirus in laboratory mouse colonies.
  • MHV exhibits diverse serotypes with distinct tissue tropisms (respiratory and enterotropic).
  • Infection outcomes vary with virus strain and host factors, affecting neonates more severely than adults.

Purpose:

  • To outline the significance of MHV in laboratory animal science.
  • To describe MHV's characteristics, including its mutability, tropism, and disease presentation.
  • To detail diagnostic and control strategies for MHV in mouse colonies.

Summary:

  • MHV is a mutable coronavirus impacting laboratory mice, with strains causing respiratory or enteric disease.
  • While adult mice often show subclinical infections, neonates are highly susceptible, though protected by passive immunity in enzootic colonies.
  • Diagnosis involves serological screening (ELISA, immunofluorescence), and control measures include culling, rederivation, or breeding cessation.

Impact:

  • MHV serves as a crucial model for studying coronaviruses, including those affecting humans.
  • Understanding MHV is vital for maintaining the integrity of biomedical research by controlling this interfering agent.
  • Effective MHV management ensures reliable experimental results and animal welfare in research settings.