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Ifosfamide in the treatment of non-Hodgkin's lymphoma
1Department of Hematology and Medical Oncology, Cleveland Clinic Foundation, OH 44195, USA.
Abstract:
Ifosfamide has been used extensively for the treatment of patients with non-Hodgkin's lymphoma (NHL). This review is limited to published series in which 30 or more evaluable patients were treated in a prospective, uniform fashion either with ifosfamide alone or in combination with other chemotherapeutic agents. Studies in which ifosfamide was used solely as part of a high-dose chemotherapy preparative regimen with autologous hematopoietic progenitor cell transplantation are not included. Three different applications of ifosfamide are addressed: (1) ifosfamide as a single agent and in combination chemotherapy for patients with previously treated NHL, (2) ifosfamide in combination chemotherapy for patients with newly diagnosed, aggressive NHL; and (3) ifosfamide in combination chemotherapy as consolidation for patients with aggressive NHL in first complete remission.
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