Related Experiment Video
Updated: Aug 14, 2026

Cavernous Nerve Stimulation and Recording of Intracavernous Pressure in a Rat
Published on: April 23, 2018
Slow injection of prostaglandin E1 decreases associated penile pain
D Gheorghiu1, M Godschalk, S Gheorghiu
1Division of Geriatrics Medicine, Medical College of Virginia, Richmond, USA.
Objectives:
A randomized, double-blind study to determine whether speed of intracavernous injection of prostaglandin E1 (PGE1) is associated with pain.
Methods:
On two separate occasions, using two different speeds of injection (5 versus 60 seconds), 11 subjects received the same dose of PGE1 that they used at home. The presence, duration, and intensity of pain were recorded.
Results:
We found that fast penile injection of PGE1 was associated with a greater intensity of pain (P = 0.04).
Conclusions:
Slow injection of PGE1 is less often associated with penile pain, the most common adverse effect of this treatment.
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