Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Albendazole-induced pseudomembranous colitis

V Shah1, C Marino, F L Altice

  • 1Section of Digestive Diseases, Yale University Medical School, New Haven, Connecticut, USA.

The American Journal of Gastroenterology
|July 1, 1996
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Individual and poly-substance use and condomless sex among HIV-uninfected adults reporting heterosexual sex in a multi-site cohort.

BMC public health·2021
Same author

Acute spondyloarthritis developing during successful treatment with dupilumab for severe atopic dermatitis.

Clinical and experimental dermatology·2021
Same author

Psychometric validation of the desire thinking questionnaire in a Turkish adolescent sample: Associations with internet gaming disorder.

Addictive behaviors·2021
Same author

The Mortality After Release from Incarceration Consortium (MARIC): Protocol for a multi-national, individual participant data meta-analysis.

International journal of population data science·2020
Same author

Totally laparoscopic radical cholecystectomy (lymphadenectomy and segment IVb-V liver resection) after incidental gallbladder carcinoma (with video).

Journal of visceral surgery·2018
Same author

Visual motion and rapid auditory processing are solid endophenotypes of developmental dyslexia.

Genes, brain, and behavior·2017

A patient with AIDS and intestinal microsporidiosis developed pseudomembranous colitis during albendazole treatment. Symptoms resolved with vancomycin, suggesting a potential link between albendazole and this condition in immunocompromised patients.

Area of Science:

  • Gastroenterology
  • Infectious Diseases
  • Pharmacology

Background:

  • Intestinal microsporidiosis is an opportunistic infection common in patients with acquired immunodeficiency syndrome (AIDS).
  • Albendazole is a standard treatment for microsporidiosis, but its potential side effects require careful monitoring.
  • Pseudomembranous colitis, often caused by Clostridium difficile, is a serious gastrointestinal complication.

Observation:

  • A patient with AIDS and intestinal microsporidiosis presented with worsening diarrhea, abdominal pain, and fever while on albendazole therapy.
  • Flexible sigmoidoscopy and stool testing confirmed pseudomembranous colitis and Clostridium difficile toxin.
  • Symptoms resolved completely after treatment with oral vancomycin.

Findings:

  • This case suggests a potential association between albendazole use and the development of pseudomembranous colitis in an immunocompromised patient.

Related Experiment Videos

  • While metronidazole has been linked to this condition, albendazole has not been previously reported as a cause.
  • The review discusses albendazole's antimicrobial spectrum, efficacy in microsporidiosis, and pathogenic mechanisms of pseudomembranous colitis in AIDS patients.

    • Implications:

    • Clinicians should consider pseudomembranous colitis in AIDS patients experiencing gastrointestinal distress during albendazole treatment.
    • Further investigation may be warranted to confirm the association between albendazole and Clostridium difficile-associated diarrhea.
    • Understanding this potential adverse effect is crucial for optimizing treatment strategies in immunocompromised populations.