Lack of association between polymorphisms in the 5-HT2A receptor gene and the antipsychotic response to clozapine
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A K Malhotra1, D Goldman, N Ozaki
1Experimental Therapeutics Branch, National Institute of Mental Health, Bethesda, MD 20892-13880, USA.
Objective:
The authors' goal was to determine whether either of two 5-HT2A receptor polymorphisms, 102-T/C and 452-His/Tyr, are associated with clozapine response.
Method:
Brief Psychiatric Rating Scale (BPRS) ratings were obtained in 70 patients with schizophrenia or schizoaffective disorder to determine their response to clozapine compared with a typical neuroleptic. Patients were genotyped with the polymerase chain reaction and restriction fragment length polymorphism analysis.
Results:
Neither 102-T/C nor 452-His/Tyr was associated with clozapine response. There were no significant differences in BPRS scores among patients with different 5-HT2A genotypes at week 10 of clozapine administration.
Conclusions:
Allelic variation in the 5-HT2A gene is not associated with individual differences in clozapine response.