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Related Experiment Videos

Androgens, brain, and behavior

D R Rubinow1, P J Schmidt

  • 1National Institute of Mental Health, Bethesda, MD 20892-1276, USA.

The American Journal of Psychiatry
|August 1, 1996
PubMed
Summary
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Androgens, including anabolic steroids, significantly impact brain function and behavior in animals and humans. Their effects on sexuality, aggression, and cognition are context-dependent, influencing psychiatric conditions.

Area of Science:

  • Neuroendocrinology
  • Behavioral Neuroscience

Background:

  • Androgens are crucial hormones influencing various physiological processes.
  • Anabolic steroids are synthetic androgens with significant biological effects.

Purpose of the Study:

  • To define androgens and anabolic steroids.
  • To describe their mechanisms of action.
  • To summarize their behavioral effects in animals and humans.

Main Methods:

  • A comprehensive literature review using MEDLINE.
  • Inclusion of pivotal earlier publications on androgens and behavior.

Main Results:

  • Androgens profoundly affect animal brain structure and function, extending beyond reproduction.
  • Inconsistent roles in humans include sexuality, aggression, cognition, emotion, and personality.

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  • Androgens are relevant to psychiatry due to gender differences and psychotoxic effects of anabolic steroids.

    • Conclusions:

    • Biological and behavioral responses to androgens are context-dependent in both animals and humans.