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Computerized Dynamic Posturography for Postural Control Assessment in Patients with Intermittent Claudication
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Computerized Dynamic Posturography for Postural Control Assessment in Patients with Intermittent Claudication

Published on: December 11, 2013

Evaluation of the coagulation and fibrinolytic systems in men with intermittent claudication

K Handa1, M Takao, J Nomoto

  • 1Department of Internal Medicine, School of Medicine, Fukuoka University, Japan.

Angiology
|June 1, 1996
PubMed

Insights

Patients with intermittent claudication show altered coagulation and fibrinolysis markers. Elevated lipoprotein(a), fibrinogen, and thrombomodulin, alongside decreased alpha 2-plasmin inhibitor, suggest endothelial injury and system activation.

Area of Science:

  • Vascular Biology
  • Hemostasis and Thrombosis

Background:

  • Intermittent claudication is a manifestation of peripheral artery disease.
  • The role of coagulation and fibrinolytic systems in intermittent claudication is not fully understood.

Purpose of the Study:

  • To investigate differences in coagulation and fibrinolytic markers between patients with intermittent claudication and matched controls.
  • To identify potential biomarkers for endothelial injury in intermittent claudication.

Main Methods:

  • Coagulation and fibrinolytic system parameters were measured in 18 male patients with intermittent claudication and 19 healthy male controls.
  • Standard laboratory assays were used to quantify various hemostatic factors.

Main Results:

  • Significantly higher levels of lipoprotein(a), thrombomodulin, fibrinogen, and alpha 1-antitrypsin were observed in patients.
  • Patients exhibited lower levels of alpha 2-plasmin inhibitor and higher levels of alpha 2-plasmin inhibitor/plasmin complex and thrombin/antithrombin III complex.
  • Prothrombin time, activated partial thromboplastin time, plasminogen, protein C, alpha 2-macroglobulin, C1-inactivator, and antithrombin III did not significantly differ.

Conclusions:

  • Coagulation and fibrinolytic systems appear activated in patients with intermittent claudication.
  • Thrombin/antithrombin III complex, alpha 2-plasmin inhibitor/plasmin complex, and thrombomodulin may indicate peripheral endothelial injury.

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