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Antibody production and engineering in plants

J K Ma1, M B Hein

  • 1Department of Immunology, UMDS Guy's Hospital, London, UK.

Annals of the New York Academy of Sciences
|May 25, 1996
PubMed
Summary

Plant biotechnology enables large-scale production of engineered antibodies for pharmaceutical use. This approach offers unique advantages for antibody manufacturing and novel applications beyond traditional research.

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Area of Science:

  • Plant biotechnology
  • Pharmaceutical industry
  • Recombinant protein production

Background:

  • Plants are a valuable resource for the pharmaceutical industry.
  • Heterologous expression systems for recombinant protein production are established.
  • Current focus is on engineering antibodies for specific end-user requirements.

Purpose of the Study:

  • To explore the potential of plant-based systems for antibody production.
  • To highlight the advantages of plants as alternative expression systems.
  • To discuss the feasibility of agricultural-scale antibody manufacturing.

Main Methods:

  • Utilizing plant biotechnology for recombinant antibody production.
  • Engineering antibodies for precise functional requirements.
  • Scaling up antibody production on an agricultural level.

Main Results:

  • Plants offer unique alternatives for bulk antibody molecule production.
  • Plant systems can assemble full-length and complex multimeric antibodies.
  • Agricultural-scale production is envisioned, offering economic advantages.

Conclusions:

  • Plant biotechnology presents a viable and economical alternative for antibody production.
  • This approach expands potential antibody applications in research and pharmaceuticals.
  • Further development can lead to novel uses of plant-produced antibodies.

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