Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Prognostic factors in malignant gliomas]

Y Ushio1, M Kochi

  • 1Dept. of Neurosurgery, Kumamoto University Medical School, Japan.

Gan to Kagaku Ryoho. Cancer & Chemotherapy
|April 1, 1996
PubMed
Summary

Histopathological diagnosis is key for malignant glioma prognosis. While multidisciplinary treatment improves survival for anaplastic astrocytoma, glioblastoma patients still face shorter prognoses, highlighting critical differences in these brain tumors.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Right sinus of Valsalva aneurysm ruptured into the right atrium in a dog.

Journal of veterinary cardiology : the official journal of the European Society of Veterinary Cardiology·2025
Same author

Genome-wide DNA methylation status as a biomarker for clinical outcomes of first-line treatment in patients with RAS wild-type metastatic colorectal cancer: JACCRO CC-13AR.

ESMO open·2025
Same author

International Harmonization of Nomenclature and Diagnostic Criteria (INHAND): Nonproliferative and Proliferative Lesions of Nonrodent Ocular Tissues.

Toxicologic pathology·2024
Same author

Persistent truncus arteriosus with an anomalous coronary artery in a cat.

Journal of veterinary cardiology : the official journal of the European Society of Veterinary Cardiology·2021
Same author

KRAS mutation leads to decreased expression of regulator of calcineurin 2, resulting in tumor proliferation in colorectal cancer.

Oncogenesis·2016
Same author

Antioxidative Activity of Amino Acids and Sulfur-containing Compounds to Superoxide: Measurement by Quenching the Chemiluminescence of a Cypridina Luciferin Analogue.

Bioscience, biotechnology, and biochemistry·2016

Area of Science:

  • Neuro-oncology
  • Cancer research
  • Pathology

Context:

  • Malignant gliomas, including anaplastic astrocytoma and glioblastoma, present distinct survival outcomes.
  • Multidisciplinary treatment has advanced anaplastic astrocytoma survival rates.
  • Glioblastoma survival remains significantly shorter despite treatment progress.

Purpose:

  • To elucidate the prognostic factors influencing survival in patients with malignant gliomas.
  • To differentiate the prognostic significance of various clinical and therapeutic elements between anaplastic astrocytoma and glioblastoma.

Summary:

  • Histopathological diagnosis is the primary prognostic determinant in malignant gliomas.
  • Younger age, better Karnofsky performance status, gross total resection (for anaplastic astrocytoma), radiotherapy, and specific chemotherapy regimens (for anaplastic astrocytoma) are associated with improved survival.
  • Glioblastoma prognosis is less influenced by gross total resection, and chemotherapy has shown limited efficacy in prolonging survival for this subtype.

Impact:

  • Provides critical insights into the differential prognoses of anaplastic astrocytoma and glioblastoma.
  • Informs clinical decision-making regarding treatment strategies and patient counseling for malignant glioma subtypes.
  • Highlights areas for future research in glioblastoma treatment optimization and prognostic factor refinement.

Related Experiment Videos