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Related Experiment Videos

Bloodstream infections with vancomycin-resistant enterococci

M A Montecalvo1, D K Shay, P Patel

  • 1Department of Medicine, New York Medical College, Valhalla, USA.

Archives of Internal Medicine
|July 8, 1996
PubMed
Summary

Vancomycin-resistant enterococci bloodstream infections primarily impact critically ill patients with prolonged antibiotic exposure. Immunocompromised individuals face a higher risk of persistent infections.

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Area of Science:

  • Infectious Diseases
  • Critical Care Medicine
  • Microbiology

Background:

  • Vancomycin-resistant enterococci (VRE) are a significant cause of nosocomial infections.
  • Understanding the characteristics of patients with VRE bloodstream infections (VRE BSI) is crucial for effective management.

Purpose of the Study:

  • To define the patient population experiencing VRE bloodstream infections.
  • To elucidate the clinical and microbiological aspects of VRE BSI.

Main Methods:

  • Retrospective chart and microbiology record review.
  • Inclusion of 73 patients with VRE bloodstream infections between June 1991 and January 1994.

Main Results:

  • Most patients (73%) were in intensive care, oncology, or AIDS units.

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  • Common comorbidities included hematologic malignancy, respiratory failure, or renal failure (83%).
  • Mortality rate was high at 63%; neutropenia and AIDS were associated with persistent infection.

    • Conclusions:

    • VRE bloodstream infections predominantly affect severely ill patients with extensive prior antibiotic treatment and prolonged hospitalization.
    • Immunocompromised patients are at increased risk for persistent VRE bloodstream infections.