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[Percutaneous absorption of venenum bufonis in vitro]

J Yu1, Y Cheng, Q Feng

  • 1Jiangxi Provincial Institute of Traditional Chinese Medicine and Materia Medica, Nanchang.

Zhongguo Zhong Yao Za Zhi = Zhongguo Zhongyao Zazhi = China Journal of Chinese Materia Medica
|September 1, 1995
PubMed
Summary

This study investigated how 1,2-propanediol and azone affect the skin absorption of resibufogenin from Venenum Bufonis. Both enhancers increased absorption, with azone notably reducing the initial absorption delay.

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Area of Science:

  • Pharmacology and Toxicology
  • Dermal Drug Delivery
  • Natural Product Chemistry

Context:

  • Venenum Bufonis contains bioactive compounds like resibufogenin.
  • Percutaneous absorption is a key route for topical and transdermal drug delivery.
  • Understanding enhancers is crucial for optimizing drug delivery through the skin.

Purpose:

  • To investigate the effects of 1,2-propanediol and azone on the in vitro percutaneous absorption of resibufogenin.
  • To quantify the impact of these enhancers on absorption rate and lag time.
  • To utilize High-Performance Liquid Chromatography (HPLC) for accurate content determination.

Summary:

  • The study employed a V-C horizontal diffusion cell and HPLC to analyze resibufogenin absorption through mouse skin.

Related Experiment Videos

  • Results showed that 1,2-propanediol increased the overall absorption of resibufogenin.
  • Azone was found to significantly decrease the lag time for resibufogenin percutaneous absorption.

    • Impact:

    • Findings provide valuable insights into optimizing the dermal delivery of resibufogenin.
    • The study highlights the potential of 1,2-propanediol and azone as enhancers for Venenum Bufonis components.
    • This research contributes to the development of novel transdermal formulations utilizing natural compounds.