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Antagonizing the differentiation and functions of human T helper type 2 cells
J E de Vries1, J M Carballido, T Sornasse
1Human Immunology Department, Research Institute of Molecular and Cellular Biology, Palo Alto, CA 94304-1104, USA.
Current Opinion in Immunology
|December 1, 1995
Abstract:
Allergen-specific T cells from atopic patients generally belong to the T-helper type 2 subset. IL-4 and IL-13 produced by these cells induce IgE synthesis by B cells and play a major role in allergic disease mediated by IgE. Recent advances in our understanding of the differentiation and IgE-inducing activities of T-helper type 2 cells suggest that targeting allergen-specific T cells may provide a novel way to intervene in allergy.