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Related Experiment Videos

Natural autoantibodies

A Coutinho1, M D Kazatchkine, S Avrameas

  • 1Institut Pasteur and Hôpital Broussais, Paris, France.

Current Opinion in Immunology
|December 1, 1995
PubMed
Summary
This summary is machine-generated.

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Natural autoantibodies, present in all individuals, are multireactive and conserved throughout life. These antibodies play roles in immune regulation, homeostasis, and resistance to infection.

Area of Science:

  • Immunology
  • Molecular Biology

Background:

  • Natural autoantibodies of IgM, IgG, and IgA classes are found in all normal individuals.
  • These antibodies react with diverse serum, cell surface, and intracellular structures.
  • They are present from birth (cord blood) and in 'antigen-free' mice, indicating a non-specific origin.

Purpose of the Study:

  • To describe the characteristics and physiological roles of natural autoantibodies.
  • To highlight their conserved nature and multireactive properties.
  • To explore their involvement in various biological processes.

Main Methods:

  • Analysis of autoantibody repertoires in normal individuals and 'antigen-free' mice.
  • Characterization of antibody reactivity with various antigens.
  • Investigation of the genetic basis (germline genes) and lack of affinity maturation.

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Main Results:

  • Natural autoantibodies possess a conserved variable-region repertoire selected by endogenous antigens.
  • They are encoded by germline genes with minimal mutations and are characteristically multireactive.
  • Unlike conventional antibodies, they do not undergo affinity maturation in normal individuals.

Conclusions:

  • Natural autoantibodies are a fundamental component of the immune system with conserved properties.
  • Their multireactivity and germline origin suggest crucial physiological functions.
  • These antibodies are implicated in immune regulation, homeostasis, repertoire selection, infection resistance, and molecular modulation.