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Related Concept Videos

Cross-reactivity00:42

Cross-reactivity

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Protein Complex Assembly02:41

Protein Complex Assembly

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Antigens Involved in Adaptive Immunity

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Autoimmune Disorders01:29

Autoimmune Disorders

Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
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Hypersensitivity Reactions: Immune-Complex Reactions01:19

Hypersensitivity Reactions: Immune-Complex Reactions

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Antibody Transfection into Neurons as a Tool to Study Disease Pathogenesis
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Ribonucleoprotein complexes as autoantigens

W J van Venrooij1, G J Pruijn

  • 1University of Nijmegen, Netherlands.

Current Opinion in Immunology
|December 1, 1995
PubMed
Summary
This summary is machine-generated.

Autoantibodies in systemic autoimmune diseases often target intracellular protein-nucleic acid complexes. Research highlights spliceosomal, nucleolar, and Ro/La ribonucleoproteins, and aminoacyl-tRNA synthetase complexes, advancing understanding of autoimmune responses.

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Last Updated: Jul 6, 2026

Antibody Transfection into Neurons as a Tool to Study Disease Pathogenesis
06:56

Antibody Transfection into Neurons as a Tool to Study Disease Pathogenesis

Published on: September 26, 2012

Anti-Nuclear Antibody Screening Using HEp-2 Cells
13:01

Anti-Nuclear Antibody Screening Using HEp-2 Cells

Published on: June 24, 2014

Generation of Two-color Antigen Microarrays for the Simultaneous Detection of IgG and IgM Autoantibodies
10:16

Generation of Two-color Antigen Microarrays for the Simultaneous Detection of IgG and IgM Autoantibodies

Published on: September 15, 2016

Area of Science:

  • Immunology
  • Molecular Biology
  • Biochemistry

Background:

  • Autoantibodies frequently target intracellular proteins and nucleic acids in systemic autoimmune diseases.
  • Autoantigens often exist as multicomponent complexes of proteins and nucleic acids.
  • Significant progress has been made in studying autoantigenic ribonucleoprotein complexes.

Purpose of the Study:

  • To review recent advancements in the understanding of autoantigenic ribonucleoprotein complexes.
  • To explore the structural and functional aspects of these complexes.
  • To discuss epitope spreading and the role of apoptosis in autoimmune responses against these complexes.

Main Methods:

  • Literature review of recent studies on autoantigenic ribonucleoprotein complexes.
  • Analysis of structural and functional data.
  • Investigation of mechanisms like epitope spreading and apoptosis in autoimmune development.

Main Results:

  • Identified key autoantigenic ribonucleoprotein complexes: spliceosomal, nucleolar, Ro/La, and aminoacyl-tRNA synthetase-tRNA.
  • Gained new structural and functional insights into these complexes.
  • Obtained important results regarding epitope spreading and the potential role of apoptosis.

Conclusions:

  • Autoantigenic ribonucleoprotein complexes are crucial targets in systemic autoimmune diseases.
  • Further research into these complexes, epitope spreading, and apoptosis can elucidate autoimmune disease pathogenesis.
  • Understanding these molecular interactions is vital for developing targeted therapies.