Related Experiment Video
Updated: Aug 15, 2026

Preclinical Assessment of the Bioactivity of the Anticancer Coumarin OT48 by Spheroids, Colony Formation Assays, and Zebrafish Xenografts
Published on: June 26, 2018
Fat, fish, fish oil and cancer
C P Caygill1, A Charlett, M J Hill
1Communicable Disease Surveillance Centre, Public Health Laboratory Service, Colindale, London, UK.
High animal fat intake correlates with increased colorectal and breast cancer risk. However, fish oil consumption shows a protective association, particularly in high animal fat consuming countries.
Area of Science:
- Nutritional Epidemiology
- Oncology
- Public Health
Background:
- Ecological studies suggest a link between dietary fat and cancer risk.
- Previous research indicates potential roles for specific fats in carcinogenesis.
Purpose of the Study:
- To investigate the association between fat consumption and cancer mortality across European countries.
- To explore the specific role of fish oil in mitigating cancer risk related to animal fat intake.
Main Methods:
- Analysis of cancer mortality data from 24 European countries.
- Correlation of mortality rates with national fat consumption data (animal, vegetable, fish oil).
- Time-lagged analysis to assess long-term effects of dietary patterns.
Main Results:
- Animal fat consumption correlated positively with colorectal and breast cancer mortality.
- Fish and fish oil consumption showed an inverse correlation with cancer mortality.
- Protective effects of fish oil were significant for colorectal and breast cancers, especially in high animal fat intake populations.
Conclusions:
- Dietary animal fat intake is associated with increased risk of colorectal and breast cancers.
- Fish oil consumption may offer protection against the carcinogenic effects of high animal fat intake.
- Public health strategies could consider dietary modifications to reduce cancer incidence.
Related Concept Videos
Structure of Lipids
mTOR Signaling and Cancer Progression
The mTOR pathway or the...
Mouse Models of Cancer Study
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
Cancer Prevention
Some...
mTOR Signaling and Cancer Progression
The mTOR pathway or the...
Cancer Survival Analysis

