[Alterations of fibrinolysis in stroke]

The fibrinolytic system has an important role as a controller of the coagulation, since plasmin digests and dissolves the fibrin clot. In this way, they have described many alterations in this system that are responsible of the thromboembolic disease, moreover stroke. This study tries to show the incidence of these alterations in a group of patients suffering from stroke, and the difference of this incidence between men and women. We obtained that the fibrinogen, tissue plasminogen activator (tPA) and plasminogen activator inhibitor (PAI-1) levels are significantly increased (p < 0.01) in the group of patients, and in the same way, there are also differences (p < 0.01) between men and women, so in the control group as in the patients group; these differences should mean that women have a major risk for suffering an stroke, but it doesn't fits the fact that stroke is more frequent in men and that they are younger when they suffer from this disease.