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[Transient global amnesia. Case-control study of 24 cases]

X C Moreno-Lugris1, J Martínez-Alvarez, F Brañas

  • 1Sección de Neurología, Servicio de Medicina Interna, Hospital Xeral-Calde, Lugo.

Revista De Neurologia
|May 1, 1996
PubMed
Summary

Transient global amnesia (TGA) is a memory disorder of unknown cause. This study found hypertension and a history of migraine are significant risk factors for TGA, suggesting potential links to vascular and neurological conditions.

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Area of Science:

  • Neurology
  • Vascular Neurology

Background:

  • Transient global amnesia (TGA) is a distinct neurological syndrome with an unclear etiology.
  • While vascular origins are commonly suspected, epilepsy and migraine have also been proposed as potential causes.
  • Understanding TGA's clinical features and risk factors is crucial for diagnosis and management.

Purpose of the Study:

  • To investigate the clinical characteristics of TGA.
  • To identify associated risk factors by comparing TGA patients with healthy and transient ischemic attack (TIA) control groups.
  • To explore potential etiological links, including vascular, epileptic, and migrainous origins.

Main Methods:

  • A case-control study involving 24 TGA patients and two control groups (24 healthy individuals and 24 TIA patients) matched for age and sex.

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  • Detailed clinical assessment of TGA patients, including cardiovascular risk factors, medical history, and neurological examinations.
  • Utilized electroencephalography (EEG) and cerebral computed tomography (CT) scans for further investigation.

    • Main Results:

    • The TGA group comprised 70% women, with an average age of 60.
    • Significant associations were found between TGA and arterial hypertension (Odds Ratio 7.86) compared to healthy controls.
    • A history of migraine was a notable risk factor for TGA in comparison to both healthy (Odds Ratio 9.47) and TIA (Odds Ratio >1.72) controls.

    Conclusions:

    • Arterial hypertension and a history of migraine are significant risk factors associated with transient global amnesia.
    • These findings suggest a potential interplay between vascular factors, migraine, and the pathophysiology of TGA.
    • Further research is warranted to elucidate the precise etiological mechanisms of TGA.