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Preclinical studies of chemotherapy and radiation therapy for pancreatic carcinoma
J M Robertson1, D S Shewach, T S Lawrence
1Department of Radiation Oncology, University of Michigan Medical Center, Ann Arbor 48109, USA.
Abstract:
The use of radiation therapy combined with 5-fluorouracil (5-FU) in the treatment of pancreatic cancer has been well established. It has been hypothesized that any benefit from combined 5-FU and radiation has been due to radiosensitization. Improved therapy could result from a better understanding of the mechanism of radiosensitization and the development of compounds capable of providing better radiosensitization. This article reviews preclinical findings on the mechanism of cytotoxicity and radiosensitization for 5-FU, fluorodeoxyuridine, thymidine analogs, and gemcitabine (2',2'-difluorodeoxycytidine) and discusses the clinical implications of these findings.