[Neurological symptoms associated with vitamin E deficiency]

Area of Science:

• Neurology
• Nutritional Science
• Pediatrics

Background:

• Vitamin E deficiency can manifest with diverse neurological symptoms in children.
• Understanding the underlying mechanisms of deficiency is crucial for effective treatment.

Observation:

• Two pediatric cases with distinct vitamin E deficiency etiologies were analyzed.
• Case 1: A 15-year-old boy with cystic fibrosis and fat malabsorption presented with neuropathies due to vitamin E deficiency (< 0.5 mg/l).
• Case 2: A 12-year-old girl exhibited isolated vitamin E deficiency with neurological signs resembling Friedrich's ataxia.

Findings:

• Both patients showed significant improvement in neurological symptoms following vitamin E supplementation.
• Intramuscular vitamin E was administered to the boy with cystic fibrosis, while the girl received oral supplementation.
• These outcomes underscore the efficacy of timely vitamin E repletion in reversing deficiency-related neurological deficits.

Implications:

• This study highlights the critical role of vitamin E in pediatric neurological function.
• Early diagnosis and targeted vitamin E supplementation can effectively manage deficiency-related neurological disorders.
• Further research into varied mechanisms of vitamin E deficiency is warranted for comprehensive patient care.