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Jejunal morphology in multiple sclerosis

M C Bateson, D Hopwood, J B MacGillivray

    Lancet (London, England)
    |May 26, 1979
    PubMed
    Summary
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    This study found no difference in jejunal biopsies between multiple sclerosis patients and controls. Gluten sensitivity does not appear to cause multiple sclerosis, making gluten-free diets unnecessary for patients.

    Area of Science:

    • Gastroenterology
    • Neurology
    • Immunology

    Background:

    • Multiple sclerosis (MS) is a chronic neurological disease.
    • Dietary interventions, including gluten exclusion, are sometimes adopted by MS patients.
    • The potential role of gluten sensitivity in MS etiology is debated.

    Purpose of the Study:

    • To investigate the association between gluten sensitivity and multiple sclerosis.
    • To compare jejunal tissue in MS patients and healthy controls.

    Main Methods:

    • Prospective survey comparing 11 MS patients with age- and sex-matched controls.
    • Analysis of jejunal biopsy samples using quantitative histology, morphometry, and electron microscopy.

    Main Results:

    Related Experiment Videos

    • No significant differences were observed in jejunal histology or morphology between MS patients and controls.
    • Electron microscopy revealed no distinct pathological changes related to gluten sensitivity in MS patients.

    Conclusions:

    • The study provides no evidence to support gluten sensitivity as a factor in the cause of multiple sclerosis.
    • Widespread adoption of gluten exclusion diets by MS patients appears unjustified based on current findings.